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BMS Active Not Yet Recruiting Study icon

Active, Not Recruiting

Trial ID CA047-004  |   NCT04349267

Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors

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Sorry, this study is no longer accepting new participants, but is still ongoing.
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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to evaluate BMS-986315 alone and in combination with nivolumab or cetuximab in participants with advanced solid tumors.

Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
:
  • Participants must have histologic confirmation of advanced (metastatic, recurrent, and/or unresectable) squamous cell carcinoma of the head and neck (SCCHN), nonsmall cell lung cancer (NSCLC), or renal cell cancer (RCC) with measurable disease per RECIST 1.1
    1. Participants expected to have received standard of care therapies including an available PD-(L)1 inhibitor
      1. Eastern cooperative oncology group performance status of 0 or 1
        1. Women of childbearing potential must agree to follow methods of contraception

          Exclusion Criteria

          Exclusion Criteria Icon
          :
          • Participants with active, known or suspected autoimmune disease
            1. Participants with a condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications
              1. Uncontrolled or significant cardiovascular disease
                1. History of or with active interstitial lung disease or pulmonary fibrosis
                  1. Prior participation in anti-natural killer cell receptor (anti-NKG2A) clinical study
                    1. History of allergy or hypersensitivity to study drug components Other protocol-defined inclusion/exclusion criteria apply
                      Additional Information *

                      Treatment Options

                      Study Arms

                      ASSIGNED INTERVENTION

                      Study Arms

                      Experimental: BMS-986315

                      ASSIGNED INTERVENTION
                      • Biological: BMS-986315

                      Study Arms

                      Experimental: BMS-986315 + cetuximab

                      ASSIGNED INTERVENTION
                      • Biological: BMS-986315, cetuximab

                      Study Arms

                      Experimental: BMS-986315 + nivolumab

                      ASSIGNED INTERVENTION
                      • Biological: BMS-986315, nivolumab

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