Share Icon Health Study Area: Cardiovascular Disease Chevron Icon Health Study Area: Genitourinary For Patients Health Study Area: Lung Cancer Page Icon Phone Icon For Caregivers Health Study Area: AutoImmune Disease Health Study Area: Melanoma Location Icon Print YouTube Icon For Parents Health Study Area: Lung Cancer Print Created with Sketch. Help Icon Green Check Icon Search Icon Instagram Created with sketchtool. Direction Arrow Icon Error Icon For Parents Health Study Area: Blood Cancer Help Icon Health Study Area: NASH Gender Both Bookmark Icon Health Study Area: Melanoma Created with Sketch. Glossary Print Health Study Area: Blood Cancer Health Study Area: Genitourinary Health Study Area: Gastrointestinal Cancer Mobile Menu Icon Created with Sketch. Health Study Area: Cardiovascular Disease Health Study Area: Women's Cancer Communities Map Icon Created with Sketch. For Caregivers Health Study Area: Fibrosis Health Study Area: AutoImmune Disease FAQs Health Study Area: Head and Neck Cancer Created with Sketch. For Clinicians Chevron Right Icon Gender Female Health Study Area: Breast Cancer Direction Arrow Icon Gender Both Right Arrow Icon LinkedIn Icon Green Check Icon Gender Male Health Study Area: Fibrosis For Patients Twitter Icon Email Icon Facebook Icon Health Study Area: Gastrointestinal Cancer Health Study Area: Head and Neck Cancer For Clinicians External Link Icon

Menu

Search BMS Clinical Trials
BMS Recruiting Study icon

Recruiting

Trial ID CA057-003  |   NCT05372354

A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma

Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • 12
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).

print Print
email Email

Nearest Recruiting Site

Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
:
  • Relapsed or refractory multiple myeloma (MM) and must: 1. have documented disease progression during or after their last myeloma therapy 2. be refractory to, intolerant to, or not a candidate for available, established therapies known to provide clinical benefit in MM
    1. Must have measurable disease
      1. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
        1. Agree to follow the CC-92480 Pregnancy Prevention Plan (PPP)

          Exclusion Criteria

          Exclusion Criteria Icon
          :
          • Known active or history of central nervous system (CNS) involvement of MM
            1. Plasma cell leukemia; Waldenstrom's macroglobulinemia; polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome; or clinically significant light-chain amyloidosis.
              1. Impaired cardiac function or clinically significant cardiac disease
                1. Previous SARS-CoV-2 infection within 14 days for asymptomatic or mild symptomatic infections or 28 days for severe/critical illness prior to Cycle 1 Day 1 (C1D1)
                  1. For Part 1: received prior therapy with CC-92480
                    1. For Part 2: received prior therapy with CC-92480, tazemetostat, BMS-986158, or trametinib
                      1. Previously received allogeneic stem-cell transplant at any time or received autologous stem-cell transplant within 12 weeks of initiating study treatment
                        1. Received any of the following within 14 days prior to initiating study treatment: 1. Plasmapheresis 2. Major surgery 3. Radiation therapy other than local therapy for myeloma associated bone lesions 4. Use of any systemic anti-myeloma drug therapy
                          1. Used any investigational agents within 28 days or 5 half-lives (whichever is shorter) prior to initiating study treatment
                            1. COVID-19 vaccine within 14 days prior to C1D1 Other protocol-defined inclusion/exclusion criteria apply
                              Additional Information *

                              Treatment Options

                              Study Arms

                              ASSIGNED INTERVENTION

                              Study Arms

                              Experimental: Part 1 Arm A: Dose Finding

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, Tazemetostat, Dexamethasone

                              Study Arms

                              Experimental: Part 1 Arm B: Dose Finding

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, BMS-986158, Dexamethasone

                              Study Arms

                              Experimental: Part 1 Arm C: Dose Finding

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, Trametinib, Dexamethasone

                              Study Arms

                              Active Comparator: Part 2 Arm D: Dose Expansion

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, Dexamethasone

                              Study Arms

                              Experimental: Part 2 Arm E: Dose Expansion

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, Tazemetostat, Dexamethasone

                              Study Arms

                              Experimental: Part 2 Arm F: Dose Expansion

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, BMS-986158, Dexamethasone

                              Study Arms

                              Experimental: Part 2 Arm G: Dose Expansion

                              ASSIGNED INTERVENTION
                              • Drug: CC-92480, Trametinib, Dexamethasone
                              Take the first step to see if you Match to a Clinical Trial – Check if you qualify
                              Check if you qualify
                              Answer some questions about Your health to see if you may match to this trial
                              Match to a Trial
                              If you are a match, click on the study to see the list of study site locations
                              Select a Study Site Location
                              Select a study site location that is convenient for you
                              Register
                              Provide your contact details for the study site to connect with you.

                              Help us enhance your website experience! Share your feedback with our team at BMS Clinical Trials to improve yours and others’ experience. Thank you