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Trial ID CA088-1005  |   NCT06121843

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18+
    Age Range
  • 19
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to establish a safe and tolerable dose of BMS-986393 in combinations with alnuctamab, mezigdomide, and iberdomide in participants with relapsed and/or refractory multiple myeloma (RRMM).

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Key Eligibility Criteria

Inclusion Criteria

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:
  • History of relapsed and/or refractory multiple myeloma (RRMM) treated with at least 3 (Part 1 and Part 2) or at least 1 but not greater than 3 prior anti-myeloma treatment regimens (Part 2)
    1. Measurable multiple myeloma (MM)
      1. Eastern Cooperative Oncology Group performance status of 0-1

        Exclusion Criteria

        Exclusion Criteria Icon
        :
        • Condition that confounds the ability to interpret data from the study
          1. Known active or history of central nervous system (CNS) involvement of MM Note: Other protocol-defined inclusion/exclusion criteria apply
            Additional Information *

            Treatment Options

            Study Arms

            ASSIGNED INTERVENTION

            Study Arms

            Experimental: Arm A: BMS-986393 + Alnuctamab

            ASSIGNED INTERVENTION
            • Drug: BMS-986393, Alnuctamab

            Study Arms

            Experimental: Arm B: BMS-986393 + Mezigdomide

            ASSIGNED INTERVENTION
            • Drug: BMS-986393, Mezigdomide

            Study Arms

            Experimental: Arm C: BMS-986393 + Iberdomide

            ASSIGNED INTERVENTION
            • Drug: BMS-986393, Iberdomide
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