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Trial ID CA224-048  |   NCT03459222

An Investigational Study of Immunotherapy Combinations in Participants With Solid Cancers That Are Advanced or Have Spread

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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to demonstrate the safety and preliminary activity with triple combinations of relatlimab in combination with nivolumab and BMS-986205, or in combination with nivolumab and ipilimumab in immunotherapy-naive and pretreated populations across select advanced tumor types.

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Key Eligibility Criteria

Inclusion Criteria

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:
  • Histologic or cytologic confirmation of select incurable solid malignancies that are advanced (metastatic and/or unresectable), with measurable disease per RECIST v1.1
    1. Available tumor tissue for biomarker analysis
      1. Eastern Cooperative Oncology Group Performance Status (ECOG) status of 0 or 1

        Exclusion Criteria

        Exclusion Criteria Icon
        :
        • Known or suspected central nervous system (CNS) metastases or with the CNS as the only site of active disease
          1. History of interstitial lung disease / pneumonitis
            1. Prior malignancy active within the previous 2 years except for locally curable cancers that have been cured, such as basal or squamous cell skin cancer
              1. Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent Other protocol-defined inclusion/exclusion criteria apply
                Additional Information *

                Treatment Options

                Study Arms

                ASSIGNED INTERVENTION

                Study Arms

                Experimental: Arm A

                ASSIGNED INTERVENTION
                • Biological: Relatlimab, Nivolumab
                • Drug: BMS-986205

                Study Arms

                Experimental: Arm B

                ASSIGNED INTERVENTION
                • Biological: Relatlimab, Nivolumab, Ipilimumab

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