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Trial ID CA244-0001  |   NCT06618287

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • 13
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.

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Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
  • Participants must have at least one measurable lesion per response evaluation criteria in solid tumors.
    1. Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.
      1. Participants must have a life expectancy of at least 3 months at the time of the first dose.

        Exclusion Criteria

        Exclusion Criteria Icon
        • Participants must not have any mixed Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) histology.
          1. Participants must not have any untreated symptomatic central nervous system (CNS) metastases.
            1. Participants must not have a history of serious recurrent infections.
              1. Participants must not have a history of severe heart disease.
                Additional Information *
                • Other protocol-defined Inclusion/Exclusion criteria apply.

                  Treatment Options

                  Study Arms

                  ASSIGNED INTERVENTION

                  Study Arms

                  Experimental: Group A

                  ASSIGNED INTERVENTION
                  • Drug: BMS-986507, Osimertinib

                  Study Arms

                  Experimental: Group B

                  ASSIGNED INTERVENTION
                  • Drug: BMS-986507, Pembrolizumab
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